The Hornady Interlock has been my go to for deer and antelope hunting in several calibers. Since they've don away with some of my favorites I've move on to others, mostly Speer Hot Core. I've had good luck getting Partitions to work, sometimes took playing with seating depth, sometimes a faster powder. With the open base faster powders seem to help obturate the Partition.
I haven't used one of the tipped variety of Barnes, just the older ones. I'm not usually a shoulder shooter, maybe a holdover from archery. Lung shot deer with TSX bullets seemed to travel further than what I was used to so I went back to the Interlock at that time.