I have a love/hate thing going on with my 22Hornet.
LOVE: The rifle is accurate, easy to carry and very effective. (an oddball 37 gr. Calhoun HP bullet over a bunch of little gun at just over 2850fps is like dynamite on groundhogs and the one Coyote hit with it didn't go another step.
HATE: Loading and handling the fiddly fragile cases. I have a bunch of W/W cases and the necks fold up if you so much as look at them wrong.
I used to use it as a calling rifle for predators, but have pretty much switched to the evil black rifles now. Plenty accurate, the 223R/5.56 is effective, and follow up shots, when needed, can't be made any easier.
Man, I spent a loooong time mulling this one over, kicking it back and forth and even had compiled a complete Hornet H&R Handi Rifle (in pieces), dies, brass - the works, until I finally decided that I should just go with the 222. I load my 222 with cast only to just over 1800 fps anyway, the brass is tough, durable, big enough, but not too big, and I would gain no advantage with the Hornet in terms of squeezing into a smaller/cuter action. Mine's in a CZ 527 Carbine (once I get the barrel cut/crowned.
I'm not saying everyone should replace their Hornets with 22s, I just did it that way because I didn't need both, but wanted at least one. I COULD get a 222 Contender barrel and I'm sure it would be a dandy package, but my 527 is the one Mauserly rifle I decided to keep - gotta have at least one Mauser.