It's no secret that I am a fan of .45 ACP/.45 Auto Rim revolvers. I have put tens of thousands of my own cast bullets through my 625-6 (5") as well as one of my favorite revolvers, my 625-8 JM Special.
These days I mostly shoot target loads, standing at 25 yards. My favored target load is a Mihec copy of the H&G #68 200 gr. SWC ahead of 4.0 grs. of Bullseye or equivalent. My guns will shoot well under 1" off a rest at 25 yards.
If you need a speedy reload for competition or self defense, you could hardly beat the home cast Lee 230 gr. TC as mentioned above (using moonclips and .45 ACP cases.
The early .45 ACP revolvers are not heat treated like the ones made after the early 1950's. They are a bit tender. However, they WILL handle good cast bullets at reasonable pressures, long term. I would NOT exceed 5.0 grs. of Bullseye behind a 230 gr. bullet.
I presume the O.P.'s revolver in question has fixed sights. That add's a complication to the equation. However, a 230 gr. Lee TC bullet ahead of 4.0-5.0 grs. of Bullseye should shoot to the sights. Keep in mind, that not every one sees the same. You have to adjust the load to YOUR eyes and revolver.
As some have said, this is a journey, not a destination. I am VERY partial to adjustable sights. Due to aging eyes, my "adjustable sights" these days are mostly Red Dot sights (and, I LOVE them). Having said that, one of my revolvers, a Ruger Bisley Vaquero .45 Colt, using Black Powder and my own cast Lyman 452664 (a 250 gr. RFN), shoots to the sights at 25 yards right out of the box. Good things DO happen from time to time!
Happy Journey!
Dale53