Wally;
When I say “serious”, I am thinking big game. When you are talking deer, the 452424 should do just fine. However, I like the large meplat on the 270SAA. If you hunt Elk, Moose, or Bear with a handgun I believe the large meplat and heavier weight to be an asset. If I am shooting my convertible on the range, then my 45 ACP cylinder and the H&G #68 (200 gr. SWC), is my choice. If small game is the target, then again, I like the .45 ACP cylinder and the same bullet (#68). Horses for courses...
FWIW,
Dale53