I woud reduce top IMR 4227 loads 20% to get to ballpark, top 2400 loads. Alliant 2400 is cleaner burning than the older Hercules, but still far less likely to leave unburned kernels.
Key to my uses is "forgiving". How wide of latitude in pressure powders work determines their status in my supply. Unique, 2400, and IMR 4227 are some powders I would prefer to not be without. Clays would be an easy substitue for Bullseye, and Universal seems to be for Unique. The Longshot/Blue Dot slot would be next, and I could live without either of those as long as I had 2400. IMR4227 is the next step beyond 2400 as far as "forgiving powders" goes, IMO. Its on the bottom end of the 5744, 4198, Reloader 7 slot. Notice that my choices of powders are NOT ball or flattened ball.